The varicocele is one of the most commen disease of urine and reproduction system in males.Its influence has been paied more attention in recent years.The WHO has listed it as the first importantreason which induces male infertility.Although many experiments have been done,the mechanism of infertility in varicocele patients is not clear to date.Therefore it is significant to carry on the research about mechanism of infertility in varicocele.This article revuews the study progress about the mechanism of infertility in varicocele in recent years.