Expression of Cox-2 and Bcl-2 in bone marrow cells of acute leukemia patients

Aim: To investigate the expression of Cox-2 and Bcl-2 in bone marrow cells of acute leukemia patients. Methods: The expressions of Cox-2 and Bcl-2 in bone marrow cells of 45 cases of untreated acute leukemia,24 cases of acute leukemia at complete remission stage,and 20 cases of normal control were detected by immunohistochemical method. Results: The positive rate and score of Cox-2 and Bcl-2 in untreated acute leukemia group were significantly higher than those of acute leukemia at complete remission stage and normal control groups(P0.05).There was no significant difference between the complete remission group and the control group(P0.05).There was positive correlation between Cox-2 and Bcl-2 expression in three groups(r=0.957, P0.05).Conclusion: The overexpression of Cox-2 and Bcl-2 may involve in the progression of leukemia.