Fabrication of ultrathin Zn(OH)2 nanosheets as drug carriers

Ultrathin two-dimensional (2D) porous Zn(OH)2 nanosheets (PNs) have been fabricated by using one-dimensional Cu nanowires as backbones. PNs have thicknesses of about 3.8 nm and pore sizes of 4~10 nm. To form "smart" porous nanosheets, DNA aptamers were covalently conjugated on the surface of PNs. These ultrathin nanosheets show good biocompatibility, efficient cellular uptake, and promising pH-stimulated drug release.