Study on the Proper Dose of Atropine in the Respiratory Supporting Therapy of Respiratory Muscle Paralysis Caused by Acute Organophosphorus Pesticide Poisoning

Objective To investigate the proper dose of atropine in the therapy of respiratory muscle paralysis (RMP) caused by acute organophosphorus pesticide poisoning(AOPP) during artificial ventilation.Methods 99 cases of RMP caused by AOPP were divided into 9 groups according to the maintaining dose of atropine.The occurring rate of atropine deficiency and atropine poisoning mortality,the survival rate,lasting time of atropine,the time of freeing of breathing machine,the mean hospitalization days were compared.Results The occurring rate of atropine deficiency and mortality was higher in group Ⅰ and Ⅱ(2 mg/h atropine) than in any other group(P0.05).No atro- pine deficiency or atropine poisoning occurred in group Ⅲ～ Ⅵ(2～5 mg/h atropine).The lasting time of atropine,the time of freeing of breathing machine and the mean hospitalization days are longer in group Ⅶ and Ⅷ than in any other groups (P0.05).Conclusion The maintaining dose of atropine with 2～5 mg/h to maintain atropinization during artificial ventilation is ideal dose in improving curative rate and decreasing mortality of patients with RMP caused by AOPP.