The effect of ultrasound degreasing on pigskin was investigated with three surface active agents:NP-10,AEO-9,SDBS. The optimal degreasing process was established by testing the indexes of degreasing rate and collagen loss rate. The result showed that ultrasound together with emulsifying agents could improve degreasing rate remarkably and the degreasing effect of SDBS was the best. The optimal degreasing condition was 0.75% SDBS treatment for 2h under ultrasound at room temperature and 1∶2.5 of material-liquid ratio. Under this optimal condition,the degreasing rate and collagen loss rate were 68.67% and 10.01%,respectively.