医学
依维莫司
PI3K/AKT/mTOR通路
内科学
mTOR抑制剂的发现与发展
内分泌系统
肿瘤科
乳腺癌
西罗莫司
癌症研究
激素受体
内分泌学
癌症
激素
信号转导
生物
细胞生物学
作者
José Baselga,Mario Campone,Martine Piccart,Howard A. Burris,Hope S. Rugo,Tarek Sahmoud,Shinzaburo Noguchi,Michael Gnant,Kathleen I. Pritchard,Fabienne Lebrun,J. Thaddeus Beck,Yoshinori Ito,Denise A. Yardley,Ines Deleu,Alejandra Perez,Thomas Bachelot,Luc Vittori,Zhiying Xu,Pabak Mukhopadhyay,David Lebwohl
标识
DOI:10.1056/nejmoa1109653
摘要
Everolimus combined with an aromatase inhibitor improved progression-free survival in patients with hormone-receptor-positive advanced breast cancer previously treated with nonsteroidal aromatase inhibitors. (Funded by Novartis; BOLERO-2 ClinicalTrials.gov number, NCT00863655.).
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