生物
细胞生物学
福明
MDia1公司
Wiskott–Aldrich综合征蛋白
Rac-GTP结合蛋白
肌动蛋白重塑
肌动蛋白
鸟嘌呤核苷酸交换因子
RAC1
GTP酶
信号转导
肌动蛋白细胞骨架
细胞骨架
细胞
生物化学
作者
Diego E. Álvarez,Hervé Agaisse
出处
期刊:Small GTPases
[Informa]
日期:2014-04-03
卷期号:5 (2): e29038-e29038
被引量:10
摘要
Vaccinia virus dissemination relies on the recruitment of the nucleation promoting factor N-WASP underneath cell-associated extracellular virus (CEVs) and subsequent recruitment and activation of the ARP2/3 complex, a major actin nucleator of the host cell. We have recently discovered that, in addition to the N-WASP/ARP2/3 pathway, vaccinia actin-based motility also relies on the small GTPase Rac1 and its downstream effector the formin-type actin nucleator FHOD1. Here we discuss the potential signaling mechanisms supporting the integration of the N-WASP/ARP2/3 and Rac1/FHOD1 pathways. We suggest the existence of a receptor tyrosine kinase family member that would integrate the Src-dependent activation of the N-WASP/ARP2/3 pathway and the GTP exchange factor-dependent activation of the Rac1/FHOD1 pathway.
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