干细胞
祖细胞
唾液腺
胚胎干细胞
再生(生物学)
干细胞疗法
病理
放射治疗
生物
医学
癌症研究
免疫学
细胞生物学
内科学
生物化学
基因
作者
Robert P. Coppes,Monique A. Stokman
出处
期刊:Oral Diseases
[Wiley]
日期:2010-08-27
卷期号:17 (2): 143-153
被引量:95
标识
DOI:10.1111/j.1601-0825.2010.01723.x
摘要
Hyposalivation underlying xerostomia after radiotherapy is still a major problem in the treatment of head and neck cancer. Stem cell therapy may provide a means to reduce radiation-induced hyposalivation and improve the quality of life of patients. This review discusses the current status in salivary gland stem cell research with respect to their potential to attenuate salivary gland dysfunction. Knowledge on the embryonic development, homeostasis and regeneration after atrophy of the salivary glands has provided important knowledge on the location of the salivary gland as well as on the factors that influence proliferation and differentiation. This knowledge has helped to locate, isolate and characterize cell populations that contain the salivary gland stem cell, although the exact tissue stem cell is still unidentified. The role that stem/progenitor cells play in the response to radiation and the factors that can influence stem/progenitor induced proliferation and differentiation are discussed. Finally, the mobilization and transplantation of stem cells and supportive cells and their potential to attenuate radiation-induced salivary gland damage are discussed. Based on the major advances made in the field of stem cell research, stem cell-based therapy has great potential to allow prevention or treatment of radiation-induced hyposalivation.
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