Fish scale, the chief waste materials generated during fish processing is however a promising and cost efficacious source of different important nutrients but unfortunately it has not received much attention. This consideration stresses to explore the proximate composition and minerals contents of fish scales from 12 different fish species collected from three different fish market in Dhaka city to evaluate their usage as potential bioactive compounds. The average carbohydrate, lipid, protein, moisture and ash contents were recorded within a range of 0.35± 0.24 to 2.18 ±0.68 %, 0.27±0.21 to 1.60± 0.08 %, 40.28 ±1.02 to 71.57± 0.64 %, 7.87± 0.57 to 20.53±0.48 % and 19.06± 0.6 to 39.55± 0.94 % respectively. The research reveals that all the twelve species of fish’s scales contained reasonable amount of micronutrients more notably calcium (3246.93±18.98 to 7930.42±60.02 mg/100g), iron (24.15±1.74 to 1360.60±10.43 mg/100g), magnesium (151.13 ±18.5 to 236.56 ±25.61 mg/100g) and phosphorous (230.40 ±5.11 to 2031. 09 ±25.01 mg/100 g).