Bio-based nanomaterials for cancer therapy

Bio-based nanomaterials have received considerable attention in cancer therapies due to their potent characteristics such as autologous pharmaceutical, synergetic effects, biocompatibility, biodegradability and biosafety. Here, we took breast cancer (BC) for example, mainly focused on six types of bioactive substances (nucleic acid, phenolics, polysaccharides, protein and peptide, lipid and cell) and their applications in bio-based nano-formulation for oncological therapies. Particularly, we have categorized the functions of these bioactive substances and exemplified the nano-systems’ composite constructions, structural characterizations, versatile properties, anti-tumor mechanisms and biological performances. Ultimately, we thoroughly discussed the present challenges and future perspectives in the emerging research frontier. We believe that this review would offer inspired ideas, promising strategies and potential pathways for designing state-of-the-bio-based-nanomaterials for cancer therapy in critical and advanced biomedical sciences.