二氧乙烷
化学发光
纳米技术
自体荧光
计算机科学
模式
荧光
生化工程
化学
材料科学
工程类
光学
物理
色谱法
社会科学
社会学
作者
Yaling Wang,Yongning Bian,Xueqian Chen,Dongdong Su
标识
DOI:10.1002/asia.202200018
摘要
Chemiluminescent probes based on 1,2-dioxetane scaffold are one of the most sensitive imaging modalities for detecting disease-related biomarkers and can obtain more accurate biological information in cells and in vivo. Due to the elimination of external light excitation, the background autofluorescence problem in fluorescence technology can be effectively avoided, providing ultrahigh sensitivity and signal-to-noise ratio for various applications. In this review, we highlight a comprehensive but concise overview of activatable 1,2-dioxetane-based chemiluminescent probes by reporting significant advances in accurate detection and bioimaging. The design principles and applications for reactive species, enzymes, and other disease-related biomarkers are systematically discussed and summarized. The challenges and potential prospects of chemiluminescent probes are also discussed to further promote the development of new chemiluminescence methods for biological analysis and diagnosis.
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