生物利用度
硒
体内
肽
化学
体外
水解物
多糖
纳米颗粒
生物化学
色谱法
药理学
材料科学
有机化学
纳米技术
生物
生物技术
水解
作者
Xieqi Luo,Fan Fan,Xinyang Sun,Peng Li,Tong Xu,Jian Ding,Yong Fang
标识
DOI:10.1016/j.ultsonch.2022.105923
摘要
Rice selenium-containing peptide TSeMMM (T) with immunomodulatory functions was isolated from selenium-enriched rice protein hydrolysates. However, its biological activity is difficult to be protected in complex digestive environments. In this study, T was encapsulated within zein and gum arabian (GA) through ultrasound treatment to improve its bioactivity and bioavailability. The zein@T/GA nanoparticles were formed using ultrasonic treatment at 360 W for 5 min with a 59.9% T-encapsulation efficiency. In vitro digestion showed that the cumulative release rate of zein@T/GA nanoparticles reached a maximum of 80.69% after 6 h. In addition, short-term animal studies revealed that the nanoparticles had an effect on the levels of tissue glutathione and improved peptides' oral bioavailability. Conclusively, these findings suggest that the ultrasonicated polysaccharide/protein system is suitable for encapsulating active small molecular peptides. Furthermore, it provides a novel foundation for studying the bioavailability of active substances in functional foods.
科研通智能强力驱动
Strongly Powered by AbleSci AI