反应性充血
医学
心脏病学
内科学
肱动脉
血压
糖尿病前期
脉冲压力
脉冲波速
四分位间距
内分泌学
内皮功能障碍
作者
Wu Chen,Yiqun Han,Yanwen Wang,Xi Chen,Xinghua Qiu,Weiju Li,Yifan Xu,Tong Zhu
出处
期刊:Hypertension
[Ovid Technologies (Wolters Kluwer)]
日期:2022-05-01
卷期号:79 (5): 1079-1090
标识
DOI:10.1161/hypertensionaha.121.18889
摘要
Vascular dysfunction is a biological pathway whereby particulate matter (PM) exerts deleterious cardiovascular effects. The effects of ambient PM on vascular function in prediabetic individuals are unclear.A panel study recruited 112 Beijing residents with and without prediabetes. Multiple vascular function indices were measured up to 7 times. The associations between vascular function indices and short-term exposure to ambient PM, including fine particulate matter (PM2.5), ultrafine particles, accumulation mode particles, and black carbon, and the modification of these associations by glucose metabolic status were examined using linear mixed-effects models.Increases in brachial artery pulse pressure, central aortic pulse pressure, and ejection duration, and decreases in subendocardial viability ratio and reactive hyperemia index were significantly associated with at least one PM pollutant in all participants, indicating increased vascular dysfunction. For example, for an interquartile range increment in 5-day moving average ultrafine particles, brachial artery pulse pressure, and central aortic pulse pressure increased 5.4% (0.8%-10.4%) and 6.2% (1.2%-11.5%), respectively. Additionally, PM-associated changes in vascular function differed according to glucose metabolic status. Among participants with high fasting blood glucose levels (≥6.1 mmol/L), PM exposure was significantly associated with increased brachial artery systolic blood pressure, central aortic systolic blood pressure, brachial artery pulse pressure, central aortic pulse pressure, and augmentation pressure normalized to a heart rate of 75 bpm and decreased subendocardial viability ratio and reactive hyperemia index. Weaker or null associations were observed in the low-fasting blood glucose group.Glucose metabolic disorders may exacerbate vascular dysfunction associated with short-term ambient PM exposure.
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