Burkitt's Lymphoma: The Role of Radiotherapy

Burkitt's lymphoma connotes a racially and geographically limited tumor of multicentric extranodal origin which is highly curable with cyclophosphamide (Cytoxan). Experience with 12 cases of Burkitt's tumor (1966–1970) prompts re-evaluation of these beliefs. Of 10 patients who underwent definitive therapy, those given Cytoxan as the primary agent achieved no remissions longer than 5 months. In 3 cases with localized disease, irradiation combined with Cytoxan produced 2 continued remissions at 56 and 11 months, respectively. Localized disease appears to be radioresponsive. The necessity for accurate definition and staging of Burkitt's lymphoma before institution of therapy is emphasized.