病毒
细胞内
动力学(音乐)
传输(电信)
理论(学习稳定性)
免疫系统
细胞
人类免疫缺陷病毒(HIV)
免疫
基本再生数
数学
体液免疫
李雅普诺夫函数
病毒学
控制理论(社会学)
生物
细胞生物学
非线性系统
物理
免疫学
计算机科学
控制(管理)
电信
人口
声学
量子力学
人工智能
人口学
社会学
机器学习
遗传学
作者
Jiazhe Lin,Rui Xu,Xiaohong Tian
标识
DOI:10.1016/j.amc.2017.08.004
摘要
Direct cell-to-cell transmission of HIV-1 is proved to be a more efficient means of virus infection than virus-to-cell transmission. In this paper, we incorporate both virus-to-cell and cell-to-cell transmissions into an HIV-1 virus model, which also contains intracellular delay and humoral immunity. By analyzing the characteristic equations, the local stability of feasible equilibria is established. By using Lyapunov functionals and LaSalle's invariance principle, it is verified that global threshold dynamics of the model can be explicitly described by immune-inactivated reproduction rate and immune-activated reproduction rate. Numerical simulations are carried out to illustrate the corresponding theoretical results.
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