Although emotional dissonance has been broadly investigated in the literature, the relationship of emotional dissonance and emotional intelligence with job-stress, burnout and well-being in nursing profession requires further exploration. This study examines the extent to which emotional dissonance and emotional intelligence are associated with job-stress, burnout and well-being among nurses working in public sector hospitals of Pakistan. The moderating role of emotional intelligence is evaluated as a key factor in the rescue of healthcare workers from job-stress and burnout thus increasing job retention. Data were collected from 379 nurses working in public sector hospitals of Pakistan through a cross-sectional quantitative research design. The results show that both emotional dissonance and emotional intelligence have significant effects on nurses' perceived job-stress, burnout and well-being. The moderating effect of emotional intelligence is also confirmed. These findings provide additional evidence for the important effects that emotional dissonance and emotional intelligence can have on nurses' job-stress, burnout and well-being. The potential benefits of emotional intelligence in the nurses' emotional work have been explored.