亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Blood Pressure, Proteinuria, and Renal Function Decline: Associations in a Large Community-Based Population

蛋白尿 医学 肾功能 血压 内科学 人口 肾脏疾病 内分泌学 环境卫生
作者
Atsushi Hirayama,Tsuneo Konta,Keita Kamei,Kazuko Suzuki,Kazunobu Ichikawa,Shouichi Fujimoto,Kunitoshi Iseki,Toshiki Moriyama,Kunihiro Yamagata,Kazuhiko Tsuruya,Kenjiro Kimura,Ichiei Narita,Masahide Kondo,Koichi Asahi,Issei Kurahashi,Yasuo Ohashi,Tsuyoshi Watanabe
出处
期刊:American Journal of Hypertension [Oxford University Press]
卷期号:28 (9): 1150-1156 被引量:53
标识
DOI:10.1093/ajh/hpv003
摘要

Hypertension and proteinuria are risk factors for adverse renal outcomes in patients with chronic kidney disease. This study investigated the associations of blood pressure and proteinuria on renal function in a community-based population. We analyzed data from a nationwide database of 141,514 subjects who participated in the annual "Specific Health Check and Guidance in Japan" checkup in 2008 and 2010. The study subjects were aged between 29 and 74 years, and the cohort comprised 40% men. We examined relationships between blood pressure levels, proteinuria at baseline, and the 2-year change in the estimated glomerular filtration rate (eGFR), which was determined using the Japanese equation. After adjusting for possible confounders, the change in the eGFR was inversely correlated with systolic blood pressure (SBP), but not diastolic blood pressure (DBP), at baseline, irrespective of the presence of proteinuria. Compared with the lowest SBP sixtile (≤118mm Hg), eGFRs declined significantly at SBPs ≥ 134mm Hg in subjects with proteinuria, while eGFRs declined significantly at SBPs ≥ 141mm Hg in those without proteinuria. At the same SBPs, renal function decline was faster and the risk for incident renal insufficiency was higher in subjects with proteinuria compared with those without proteinuria. This study showed that a difference in SBP, but not DBP, is independently associated with a rapid eGFR decline in the general Japanese population, and that the association of SBP on the decline of renal function was greater in subjects with proteinuria compared with those without proteinuria.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
13秒前
ldqm发布了新的文献求助10
19秒前
827584450应助zm采纳,获得10
21秒前
zm完成签到,获得积分10
48秒前
49秒前
53秒前
seven_74521发布了新的文献求助10
55秒前
1分钟前
Wcy发布了新的文献求助10
1分钟前
深情安青应助Wcy采纳,获得10
1分钟前
fengfenghao完成签到,获得积分10
1分钟前
nicolaslcq完成签到,获得积分10
1分钟前
2分钟前
2分钟前
本本完成签到 ,获得积分10
3分钟前
任性大米完成签到 ,获得积分10
3分钟前
bc完成签到,获得积分0
3分钟前
nolan完成签到 ,获得积分10
3分钟前
小马甲应助科研通管家采纳,获得10
4分钟前
bc举报安静的火车求助涉嫌违规
4分钟前
4分钟前
5分钟前
激动的似狮完成签到,获得积分10
5分钟前
5分钟前
Wcy发布了新的文献求助10
5分钟前
XX完成签到,获得积分10
5分钟前
Beyond095完成签到 ,获得积分10
5分钟前
wanci应助Wcy采纳,获得10
5分钟前
所所应助XX采纳,获得10
5分钟前
6分钟前
朱佳慧发布了新的文献求助10
6分钟前
7分钟前
无奈的代珊完成签到 ,获得积分10
7分钟前
所所应助朱佳慧采纳,获得10
7分钟前
7分钟前
noss发布了新的文献求助10
7分钟前
8分钟前
8分钟前
NexusExplorer应助来这里了采纳,获得10
8分钟前
kbcbwb2002完成签到,获得积分10
8分钟前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Technologies supporting mass customization of apparel: A pilot project 450
Mixing the elements of mass customisation 360
Периодизация спортивной тренировки. Общая теория и её практическое применение 310
the MD Anderson Surgical Oncology Manual, Seventh Edition 300
Nucleophilic substitution in azasydnone-modified dinitroanisoles 300
Political Ideologies Their Origins and Impact 13th Edition 260
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3780810
求助须知:如何正确求助?哪些是违规求助? 3326338
关于积分的说明 10226598
捐赠科研通 3041516
什么是DOI,文献DOI怎么找? 1669478
邀请新用户注册赠送积分活动 799063
科研通“疑难数据库(出版商)”最低求助积分说明 758732