The aim of our study was to determine the efficacy of Platelet-Rich Plasma (PRP) treatment in symptomatic osteoarthritic knee. PRP has been utilized to treat cartilage lesions with increasing frequency to regenerate tissue homeostasis and to delay the progression of knee Osteoarthritis (OA). As per our knowledge not many studies with follow ups longer than 18 months have been published. Here we are presenting the outcome in our patients at the end of 2 years