亚科
细胞致死膨胀毒素
毒素
生物
细菌
蛋白质亚单位
微生物学
微生物毒素
遗传学
计算生物学
基因
出处
期刊:New Journal of Science
[Hindawi Limited]
日期:2014-09-25
卷期号:2014: 1-26
被引量:7
摘要
Some of the most potent toxins produced by plants and bacteria are members of a large family known as the AB toxins. AB toxins are generally characterized by a heterogenous complex consisting of two protein chains arranged in various monomeric or polymeric configurations. The newest class within this superfamily is the cytolethal distending toxin (Cdt). The Cdt is represented by a subfamily of toxins produced by a group of taxonomically distinct Gram negative bacteria. Members of this subfamily have a related AB-type chain or subunit configuration and properties distinctive to the AB paradigm. In this review, the unique structural and cytotoxic properties of the Cdt subfamily, target cell specificities, intoxication pathway, modes of action, and relationship to the AB toxin superfamily are compared and contrasted.
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