大肠杆菌
中性粒细胞弹性蛋白酶
微生物学
细菌
化学
肠杆菌科
败血症
生物
细菌外膜
弹性蛋白酶
生物化学
革兰氏阴性菌
酶
炎症
免疫学
基因
遗传学
作者
Abderrazzaq Belaaouaj,Kwang Sik Kim,Steven D. Shapiro
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2000-08-18
卷期号:289 (5482): 1185-1187
被引量:338
标识
DOI:10.1126/science.289.5482.1185
摘要
In determining the mechanism of neutrophil elastase (NE)-mediated killing of Escherichia coli, we found that NE degraded outer membrane protein A (OmpA), localized on the surface of Gram-negative bacteria. NE killed wild-type, but not OmpA-deficient, E. coli. Also, whereas NE-deficient mice had impaired survival in response to E. coli sepsis, as compared to wild-type mice, the presence or absence of NE had no influence on survival in response to sepsis that had been induced with OmpA-deficient E. coli. These findings define a mechanism of nonoxidative bacterial killing by NE and point to OmpA as a bacterial target in host defense.
科研通智能强力驱动
Strongly Powered by AbleSci AI