生物
细胞融合
细胞生物学
肌发生
脂质双层融合
合子
合胞滋养细胞
细胞内
计算生物学
细胞
心肌细胞
胚胎发生
膜
胚胎
遗传学
胎盘
胎儿
怀孕
作者
Meital Oren‐Suissa,Benjamin Podbilewicz
标识
DOI:10.1016/j.tcb.2007.09.004
摘要
Most readers of this review originated from a sperm-egg fusion event. Cell fusion is a process that is crucial at many intersections later during development. However, we do not know which molecules (fusogens) fuse the membranes of gametes to form zygotes, myoblasts to form myotubes in muscles, macrophages to form osteoclasts in bones, or cytotrophoblasts to form syncytiotrophoblasts in placentas. There are five gold standards that can be applied for the identification of genuine fusogens. Based on these criteria, a numerical score can be used to assess the likelihood of protein fusogenicity. We compare distinct families of candidate developmental, viral and intracellular fusogens and analyze current models of membrane fusion.
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