Molecular Mechanisms of IFN-γ to Up-Regulate MHC Class I Antigen Processing and Presentation

IFN-γ up-regulates MHC class I expression and antigen processing and presentation on cells, since IFN-γ can induce multiple gene expressions that are related to MHC class I antigen processing and presentation. MHC class I antigen presentation-associated gene expression is initiated by IRF-1. IRF-1 expression is initiated by phosphorylated STAT1. IFN-γ binds to IFN receptors, and then activates JAK1/JAK2/STAT1 signal transduction via phosphorylation of JAK and STAT1 in cells. IFN-γ up-regulates MHC class I antigen presentation via activation of JAK/STAT1 signal transduction pathway. Mechanisms of IFN-γ to enhance MHC class I antigen processing and presentation were summarized in this literature review.