粘合连接
封堵器
血脑屏障
紧密连接
细胞生物学
脊髓
生物
药物输送到大脑
分离(微生物学)
钙粘蛋白
病理
神经科学
免疫学
中枢神经系统
医学
细胞
生物化学
微生物学
作者
Shujun Ge,Joel S. Pachter
标识
DOI:10.1016/j.jneuroim.2006.05.012
摘要
The isolation and culture of spinal cord microvascular endothelial cells (SCMEC), which form the blood–spinal cord barrier (BSCB), is described. Though morphologically similar to brain microvacular endothelial cells (BMEC) that form the blood–brain barrier (BBB), SCMEC express reduced amounts of several prominent BBB proteins, including tight junction-associated proteins ZO-1 and occludin, adherens junction-associated proteins β-catenin and VE-cadherin, and the efflux transporter P-glycoprotein. These distinguishing features may reflect more widespread differences between the BBB and BSCB that impact physiological and pathophysiological processes.
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