上睑下垂
脂质过氧化
GPX4
程序性细胞死亡
免疫系统
败血症
生物
谷胱甘肽过氧化物酶
抗氧化剂
免疫学
细胞凋亡
生物化学
超氧化物歧化酶
作者
Ashley J. Russo,Vijay Rathinam
标识
DOI：10.1016/j.chom.2018.06.010
摘要
Glutathione peroxidase 4 (GPX4) is an antioxidant enzyme that protects cells from lipid peroxidation. In this issue of Cell Host & Microbe, Kang et al. (2018) report that GPX4 is a negative regulator of the pyroptotic cell death pathway and plays an important role in inhibiting lethal inflammation associated with sepsis.
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