下橄榄核
齿状核
医学
小脑
神经科学
延髓
红核
变性(医学)
病因学
眼球链接调节
核心
病理
中枢神经系统
心理学
统计
条件作用
经典条件反射
数学
作者
Hongquan Wang,Yumin Wang,Ruitong Wang,Yanfeng Li,Peifu Wang,Jilai Li,Jichen Du
标识
DOI:10.1016/j.brainres.2019.04.024
摘要
Hypertrophic olivary degeneration (HOD) is a rare form of trans-synaptic degeneration characterized by hypertrophy of the inferior olivary nucleus situated in the olivary body, part of the medulla oblongata, representing a major source of input to the cerebellum. HOD typically results from focal lesions interrupting connections from the inferior olive within the dentato-rubro-olivary pathway (DROP), a region also known as the Guillain-Mollaret triangle (GMT) (red nucleus, inferior olivary nucleus, and contralateral dentate nucleus). Clinically, HOD presents classically as palatal tremor and can include dentatorubral tremor and/or ocular myoclonus. Oppenheim first described the enlargement of the ION in his post-mortem study. Since then, a limited number of cases have been reported in the literatures. Thus, we intended to describe the definition, pathophysiology, clinical features, radiological features, diagnosis, and current management of HOD. We provide a comprehensive review of HOD focusing on etiology. The present review may lead to a better understanding of HOD clinical characteristic with the goal of contributing to existing knowledge of this rare disease.
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