医学
神经影像学
疾病
脑脊液
病理
阿尔茨海默病
淀粉样蛋白(真菌学)
精神科
作者
Bliss E. O’Bryhim,Jonathan B. Lin,Gregory P. Van Stavern,Rajendra S. Apte
出处
期刊:Ophthalmology
[Elsevier]
日期:2021-10-01
卷期号:128 (10): 1489-1491
被引量:17
标识
DOI:10.1016/j.ophtha.2021.02.016
摘要
Preclinical Alzheimer’s disease (AD) is a recognized disease stage in which amyloid begins to accumulate within the central nervous system before the onset of disease symptoms. Preclinical AD is diagnosed by measuring amyloid burden either by neuroimaging with amyloid markers or by direct measurement within cerebrospinal fluid (CSF).1 However, these methods are time-consuming and invasive. Our prior study demonstrated alterations in the foveal avascular zone (FAZ) of eyes from subjects with preclinical AD compared with eyes from age-matched controls.
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