Multi‐Caged IrOx for Facile Preparation of “Six‐in‐One” Nanoagent for Subcutaneous and Lymphatic Tumors Inhibition against Recurrence and Metastasis

Abstract Single nanocarriers with intrinsic characteristics of diagnosis, effective therapy against solid malignancies with fatal metastasis, and tumor microenvironment regulation are promising in construction of a simple and effective multimode nanotheranostic system. Herein, multi‐caged IrO x nanocarriers are fabricated by direct thermal hydrolysis strategy, which exhibit good sono‐photodynamic response, outstanding gemstone spectral computed tomography, and photoacoustic (PA) imaging capabilities, universal loading, and pinpoint drug release properties. As a proof of concept, a gemstone spectral computed tomography/PA/fluorescence imaging–guided oxygen self‐sufficient sono‐photo‐chemotherapy nanoagent by simple loading of doxorubicin is constructed. The remarkable synergistic therapy and excellent hypoxia releasing capabilities can remove both subcutaneous and sentinel lymph nodes metastasis tumors, and effectively suppress tumor recurrence and lung metastasis, thus greatly prolonging survival time. The study provides an attractive candidate to construct a “six‐in‐one” (tri‐modal therapies and three imaging modalities) tumor theranostic system.