医学
病理生理学
上睑下垂
内科学
十二指肠
胃肠病学
炎症
炎症体
作者
Jan Tack,Jolien Schol,Karen Van den Houte,I‐Hsuan Huang,Florencia Carbone
标识
DOI:10.14309/ajg.0000000000001077
摘要
For up to 2 decades, pathophysiological research in functional dyspepsia focused on gastric sensorimotor dysfunction underlying symptom generation. Recent pathophysiological research has focused on low-grade inflammation in the duodenal mucosa. Emerging evidence confirms a loss of mucosal integrity in the duodenum in functional dyspepsia, and this is confirmed in a confocal laser endomicroscopy study demonstrating altered mucosal barrier function and pyroptosis. This technique may help to establish underlying mechanisms and evaluate novel therapeutic approaches to functional dyspepsia.
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