甾醇调节元件结合蛋白
转录因子
胆固醇
细胞生物学
甾醇
化学
生物
生物化学
内质网
基因
作者
Renhong Yan,Pingping Cao,Wenchao Song,Hui‐Fen Qian,Ximing Du,Hudson W. Coates,Xin Zhao,Yaning Li,Shuai Gao,Xin Gong,Ximing Liu,Jianhua Sui,Jianlin Lei,Hongyuan Yang,Andrew Brown,Qiang Zhou,Chuangye Yan,Nieng Yan
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-03-05
卷期号:371 (6533)
被引量:38
标识
DOI:10.1126/science.abb2224
摘要
A cellular cholesterol sensor Cholesterol levels in cells are controlled by the sterol regulatory element–binding protein (SREBP) pathway. When the cell has sufficient cholesterol, the transcription factor that regulates cholesterol metabolism is sequestered at the endoplasmic reticulum membrane, but when cholesterol is depleted, the transcription factor is released to activate the expression of genes involved in cholesterol synthesis and uptake. Yan et al. determined the structure of a central complex in human SREBP containing the proteins Scap and Insig-2. These two membrane-embedded proteins undergo 25-hydroxycholesterol (25HC)–dependent association and must dissociate for the pathway to be activated. The structure shows that 25HC is sandwiched between Scap and Insig-2 to facilitate their association. A mutational analysis is consistent with the structural model. Science , this issue p. eabb2224
科研通智能强力驱动
Strongly Powered by AbleSci AI