医学
癌症
生物标志物
胃切除术
下调和上调
内科学
肿瘤科
免疫组织化学
病理
胃肠病学
生物
基因
生物化学
作者
Masahiro Sasahara,Mitsuro Kanda,Dai Shimizu,Chie Tanaka,Yoshikuni Inokawa,Norifumi Hattori,Masamichi Hayashi,Goro Nakayama,Yasuhiro Kodera
出处
期刊:Anticancer Research
[Anticancer Research USA Inc.]
日期:2021-01-30
卷期号:41 (2): 609-617
被引量:2
标识
DOI:10.21873/anticanres.14812
摘要
Background/Aim: Disease recurrence is frequently observed after curative resection of advanced gastric cancer resulting in a poor prognosis. In the present study, we identified a candidate biomarker to predict recurrence and prognosis after curative resection of gastric cancer. Materials and Methods: A transcriptome analysis was conducted using surgically resected cancerous tissue from patients with metastatic gastric cancer to identify genes that are upregulated in primary and metastatic tissues. Results: Ring finger protein, transmembrane 2 (RNFT2) mRNA expression was upregulated in primary gastric cancer tissues and metastases compared with non-cancerous tissues. RNFT2 expression in gastric cancer cell lines was positively correlated with the EMT-related molecules GSC, MMP9, and RAC1. The RNFT2 high expression group exhibited a significantly shorter postoperative overall survival. Peritoneal recurrence was significantly higher in the RNFT2 high expression group. Conclusion: RNFT2 mRNA expression predicts peritoneal recurrence and is a potential prognostic biomarker for gastric cancer following curative gastrectomy.
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