药物发现
背景(考古学)
药品
体内
计算生物学
药物开发
三维细胞培养
细胞培养
临床试验
生物
医学
药理学
生物信息学
遗传学
古生物学
作者
Susan Breslin,Lorraine O’Driscoll
标识
DOI:10.1016/j.drudis.2012.10.003
摘要
Cells, grown as monolayers (2D models), are routinely used as initial model systems for evaluating the effectiveness and safety of libraries of molecules with potential as therapeutic drugs. While this initial screening precedes preclinical animal studies before advancing to human clinical trials, cultured cells frequently determine the initial, yet crucial, 'stop/go' decisions on the progressing of the development of a drug. Growing cells as three-dimensional (3D) models more analogous to their existence in vivo, for example, akin to a tumour, and possibly co-cultured with other cells and cellular components that naturally occur in their microenvironment may be more clinically relevant. Here, in the context of anti-cancer drug screening, we review 2D and 3D culture approaches, consider the strengths and relevance of each method.
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