医学
激素替代疗法(女性对男性)
内科学
血栓调节蛋白
血管性血友病因子
冠状动脉疾病
内分泌学
内皮
促炎细胞因子
透皮
胃肠病学
内皮干细胞
炎症
血小板
药理学
生物
凝血酶
生物化学
睾酮(贴片)
体外
作者
Ingebjørg Seljeflot,Harald Arnesen,A. E. Hofstad,Ingrid Os
出处
期刊:Thrombosis and Haemostasis
[Georg Thieme Verlag KG]
日期:2000-01-01
卷期号:83 (06): 944-948
被引量:45
标识
DOI:10.1055/s-0037-1613947
摘要
Summary The effects of 12 months hormone replacement therapy (HRT) on biochemical markers associated with endothelial function were studied in 98 postmenopausal women with CAD, who were randomized to transdermal HRT or a control group. A significant reduction in the levels of von Willebrand factor in the HRT-group compared to controls was seen after 3 months, maintained after 12 months (p <0.001). Significant reduction in the HRT-group compared to controls was also seen in VCAM-1 after 3 months, sustained after 12 months (p = 0.013 and p = 0.045, respectively), and E-selectin was reduced by about 20% after 3 months on HRT, the reduction being statistically significant after 12 months (p <0.001). Significantly reduced levels of ICAM-1 were also seen after 12 months (p = 0.048). No effects could be observed on tPA-antigen or thrombomodulin. The reduction in procoagulant and proinflammatory markers of endothelial function after long-term transdermal HRT could indicate a beneficial effect on the endothelium and thus a potentially modulating effect on the progression of atherosclerosis in women with CAD.
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