医学
增生性瘢痕
增生性瘢痕
疤痕
机制(生物学)
风险因素
重症监护医学
外科
皮肤病科
病理
哲学
认识论
作者
Liselotte Butzelaar,Magda M. W. Ulrich,Aebele B. Mink van der Molen,Frank B. Niessen,R.H.J. Beelen
标识
DOI:10.1016/j.bjps.2015.11.015
摘要
Objective The study aims to provide an overview of risk factors for hypertrophic scarring. Background Hypertrophic skin scarring remains a major concern in medicine and causes considerable morbidity. Despite extensive research on this topic, the precise mechanism of excessive scarring is still unknown. In addition, the current literature lacks an overview of the possible risk factors in the development of hypertrophic scars. Methods PubMed searches were performed on risk factors for hypertrophic scar (HTS) formation. Results Eleven studies suggesting nine factors associated with HTS formation were found. Studies concerning chemotherapy, age, stretch, infection, and smoking have a moderate to high strength of evidence, but some other factors have not been studied in a convincing manner or are still disputed. Conclusions Risk factors for HTS formation are young age, bacterial colonization, and skin subjected to stretch. Chemotherapy, statins, and smoking seem to play a protective role in HTS formation.
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