生物
肠道菌群
微量营养素
人类健康
微生物代谢
免疫系统
寄主(生物学)
营养物
细菌
生态学
生物化学
免疫学
化学
医学
遗传学
环境卫生
有机化学
作者
Daotong Li,Pan Wang,Pengpu Wang,Xiaosong Hu,Fang Chen
标识
DOI:10.1080/10408398.2017.1363708
摘要
The gut microbiota is a complex ecosystem consisted of trillions of microbes that have co-evolved with their host for hundreds of millions of years. During the last decade, a growing body of knowledge has suggested that there is a compelling set of connections among diet, gut microbiota and human health. Various physiological functions of the host, ranging from metabolic and immune regulation to nerve and endocrine development, are possibly mediated by the structural components of microbial cell or the products of microbial metabolism, which are greatly influenced by dietary macronutrients and micronutrients. Thus, governing the production and activity of these microbial-associated small molecules and metabolites through dietary intervention may provide promising strategies for the improvement of human health and disease. In this review article, we first provide an overview of current findings about the intimate interrelationships between diet and gut microbiota. We also introduce the physiological effects of some microbial-associated small molecules and metabolites on the host as well as the detailed signaling mechanisms.
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