Analysis of Solanum Americanum Mill. by Ultrafast Liquid Chromatography with Diode Array and Time-Of-flight Mass Spectrometry Detection with Evaluation of Anti-Inflammatory Properties in Rodent Models

Solanum americanum Mill. has been traditionally used for the treatment of fever, stomachache, skin diseases, gynecological disorders, and different kinds of inflammation. This study evaluated the anti-inflammatory response of different extracts obtained from ripe fruits of S. americanum Mill., in experimental models and evaluated them qualitatively using ultrafast liquid chromatography with diode array and time-of-flight mass spectrometry (UFLC-DAD/TOF-MS). The inflammatory response of four extracts of ripe fruits was evaluated for the systemic and topical anti-inflammatory activities. The compounds in each extract were identified using UFLC-DAD-TOF/MS. A total of 34 compounds was identified in the four extracts. The best results were obtained in compounds from the aqueous and chloroform extracts. This study demonstrated a significant anti-inflammatory activity for the compounds present in fruit of S. americanum Mill.