Direct Allylation of Aliphatic Primary Amines via Al(OTf)3-Catalyzed One-Pot Four-Component Reaction

An amine-methylchloroformate-paraformaldehyde-styrene condensation catalyzed by aluminium(III) triflate is described, leading to the synthesis of allylamides. This condensation provides an efficient method for the N-carbonylation and N-allylation of various aliphatic primary amines in good to excellent yields.