生物
荧光原位杂交
浆细胞白血病
融合基因
前淋巴细胞白血病
分子生物学
慢性淋巴细胞白血病
核型
中期
癌症研究
白血病
多发性骨髓瘤
免疫学
遗传学
基因
染色体
作者
Tomohiro Ishigaki,Koji Sasaki,Ken Watanabe,N Nakamura,Shigeo Toyota,Hirofumi Kobayashi,Shuji Tohda
出处
期刊:Cancer genetics and cytogenetics
[Elsevier]
日期:2010-08-01
卷期号:201 (1): 62-65
被引量:5
标识
DOI:10.1016/j.cancergencyto.2010.05.006
摘要
The IGH/CCND1 fusion gene has been reported in many hematologic tumors such as mantle cell lymphoma, chronic lymphocytic leukemia, prolymphocytic leukemia, multiple myeloma, and plasma cell leukemia. We report a case of plasma cell leukemia showing five IGH/CCND1 fusion signals by interphase fluorescence in situ hybridization (FISH). Conventional cytogenetic analysis and multicolor spectral karyotyping showed a complex karyotype that did not include t(11;14). Metaphase FISH studies revealed three IGH/CCND1 fusion signals, two of which were amplified signals. These findings indicate that IGH/CCND1 fusion gene was amplified and interspersed in several chromosomes. The patient was treated with intensive chemotherapy. However, the clinical course was very aggressive. The amplification of the IGH/CCND1 fusion gene may contribute to the aggressive course of the disease. To our knowledge, this is the first case showing amplification of the IGH/CCND1 gene in plasma cell neoplasms.
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