The single-step synthesis of a DNA tetrahedronElectronic supplementary information (ESI) available: stoichiometry control. See http://www.rsc.org/suppdata/cc/b4/b402293a/

A tetrahedral nanostructure whose edges are DNA double helices self-assembles spontaneously when four appropriately designed oligonucleotides are annealed together in solution; the ease of synthesis, rigidity, and adaptability of this construct make it a promising candidate as a cage for other large molecules and as a building block for more complicated nanostructures.