胰腺癌
N6-甲基腺苷
癌症研究
核糖核酸
小RNA
生物
癌症
计算生物学
医学
化学
内科学
生物信息学
肿瘤科
生物化学
甲基转移酶
基因
甲基化
作者
Xiaoge Hu,Xiangxiang Lei,Jinhui Guo,Wen Fu,Wen Sun,Qiliang Lu,Wei Su,Qiuran Xu,Kangsheng Tu
标识
DOI:10.3389/fonc.2022.927640
摘要
Pancreatic cancer (PC) is one of the most common malignant cancers, ranking the seventh highest causes of cancer-related deaths globally. Recently, RNA N6-methyladenosine (m6A) is emerging as one of the most abundant RNA modifications in eukaryote cells, involved in multiple RNA processes including RNA translocation, alternative splicing, maturation, stability, and degradation. As reported, m6A was dynamically and reversibly regulated by its "writers", "erasers", and "readers", Increasing evidence has revealed the vital role of m6A modification in the development of multiple types of cancers including PC. Currently, aberrant m6A modification level has been found in both PC tissues and cell lines. Moreover, abnormal expressions of m6A regulators and m6A-modified genes have been reported to contribute to the malignant development of PC. Here in this review, we will focus on the function and molecular mechanism of m6A-modulated RNAs including coding RNAs as well as non-coding RNAs. Then the m6A regulators will be summarized to reveal their potential applications in the clinical diagnosis, prognosis, and therapeutics of PC.
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