芍药苷
萃取(化学)
体内
色谱法
根(腹足类)
化学
传统医学
溶剂
药理学
医学
高效液相色谱法
生物化学
植物
生物
生物技术
作者
Yu Zhao,Haofang Wan,Jiehong Yang,Yan Huang,Yu He,Chang Li
标识
DOI:10.1016/j.ultsonch.2022.105968
摘要
Natural deep eutectic solvent (NaDES) is widely applied in the extraction of nutrients from natural resources as a greener alternative for fossil solvent. In the present work, 27 different NaDESs were screened for the extraction of paeoniflorin (PF) and galloyl paeoniflorin (GPF) from Radix Paeoniae Rubra (RPR). After screening and extraction parameter optimization, the extraction yields of PF and GPF reached up to 182.8 mg/g and 77.4 mg/g with the selected NaDES, ChCl-Sor. Furthermore, the antioxidant activity in vitro and neuroprotectivity in vivo of the 'ready-to-use' extracts were evaluated comprehensively. Especially in vivo, the cerebral ischemic/ reperfusion injury model was established in rats and the protective effects of the RPR extracts were determined. The results not only proved that NaDES is a valuable green extraction media, but also indicated the safety and potential pharmaceutical application of NaDES based 'ready-to-use' extracts from medical plants.
科研通智能强力驱动
Strongly Powered by AbleSci AI