促红细胞生成素肝细胞(Eph)受体
以法林
结直肠癌
EPH受体A2
转移
血管生成
医学
受体酪氨酸激酶
癌症研究
癌症
生物信息学
生物
病理
受体
内科学
作者
Stavros P. Papadakos,Leonidas Petrogiannopoulos,Alexandros Pergaris,Stamatios Theocharis
摘要
The EPH/ephrin system constitutes a bidirectional signaling pathway comprised of a family of tyrosine kinase receptors in tandem with their plasma membrane-bound ligand (ephrins). Its significance in a wide variety of physiologic and pathologic processes has been recognized during the past decades. In carcinogenesis, EPH/ephrins coordinate a wide spectrum of pathologic processes, such as angiogenesis, vessel infiltration, and metastasis. Despite the recent advances in colorectal cancer (CRC) diagnosis and treatment, it remains a leading cause of death globally, accounting for 9.2% of all cancer deaths. A growing body of literature has been published lately revitalizing our scientific interest towards the role of EPH/ephrins in pathogenesis and the treatment of CRC. The aim of the present review is to present the recent CRC data which might lead to clinical practice changes in the future.
科研通智能强力驱动
Strongly Powered by AbleSci AI