区域选择性
碳负离子
化学
吡啶
钾
药物化学
组合化学
有机化学
催化作用
作者
Yan Li,Chenxu Zheng,Zhi‐Jiang Jiang,Jianbo Tang,Bencan Tang,Zhanghua Gao
摘要
A regioselective deuteration at the β- and γ-position of pyridines is reported. Efficient deuteration occurred with a combination of KOtBu and DMSO-d6, replenishing the prevailing α-deuteration of the pyridine systems. Preliminary mechanistic studies suggested that the dimsyl carbanion acts as one of the key intermediates.
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