生物
蛋白质组学
代谢物
计算生物学
代谢组学
肠道菌群
人体微生物群
微生物群
遗传学
生物信息学
生物化学
基因
作者
Xiaohui Zhao,Xinglin Yang,Howard C. Hang
出处
期刊:Biochemistry
[American Chemical Society]
日期:2022-01-06
卷期号:61 (24): 2822-2834
被引量:7
标识
DOI:10.1021/acs.biochem.1c00758
摘要
The microbiota have emerged as an important factor in host physiology, disease, and response to therapy. These diverse microbes (bacteria, virus, fungi, and protists) encode unique functions and metabolites that regulate intraspecies and interspecies interactions. While the mechanisms of some microbiota species and metabolites have been elucidated, the diversity and abundance of different microbiota species and their associated pathways suggest many more metabolites and mechanisms of action remain to be discovered. In this Perspective, we highlight how the advances in chemical proteomics have provided new opportunities to elucidate the molecular targets of specific microbiota metabolites and reveal new mechanisms of action. The continued development of specific microbiota metabolite reporters and more precise proteomic methods should reveal new microbiota mechanisms of action, therapeutic targets, and biomarkers for a variety of human diseases.
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