化学
醛
组合化学
路易斯酸
盐(化学)
过渡金属
反应条件
有机化学
催化作用
作者
S. P. Singh,Rina Mahato,Pragya Sharma,Naveen Yadav,Nagaraju Vodnala,Chinmoy Kumar Hazra
标识
DOI:10.1002/chem.202104545
摘要
This work describes a mild and robust double hydroarylation strategy for the synthesis of symmetrical /unsymmetrical diaryl- and triarylmethanes in excellent yields using Lambert salt (0.2-1.0 mol%). Despite the anticipated challenges associated with controlling selective product formation, unsymmetrical diaryl- and triarylmethanes products are obtained unprecedentedly. A highly efficient gram scale reaction has also been reported (TON for symmetrical product=475 and for unsymmetrical product=390). The synthetic utility of the methodology is demonstrated by the preparation of several unexplored diaryl- and triarylmethane-based biologically relevant molecules, such as arundine, vibrindole A, turbomycin B, and certain anti-inflammatory agents. A total synthesis of an anti-breast-cancer agent is also demonstrated. Control experiments, Hammett analysis, HRMS and GC-MS studies reveal the reaction intermediates and reaction mechanism.
科研通智能强力驱动
Strongly Powered by AbleSci AI