Searching for the link between inflammaging and sarcopenia

• Skeletal muscle might be the central integrator controlling both sarcopenia and inflammation in an aging biological system. • Adults suffering from aging were more likely to develop obesity, sarcopenia, sarcopenia obesity and metabolic disease, creating a vicious cycle, making aging a mixed complex of a number of morbid alterations that converge to determine a person's "frailty". • Over time, the ongoing and increasing presence of inflammatory cytokines, adipokines and myokines in the serum during aging and risk factor conditions may render the muscle more vulnerable to developing sarcopenia.