环丙烷化
叶立德
化学
废止
部分
硫黄
喹啉
级联
立体化学
药物化学
组合化学
有机化学
催化作用
色谱法
作者
Qing‐Song Dai,Junlong Li,Qiwei Wang,Shuangqiao Yang,Ying-Mao Tao,Mei-Hao He,Qingzhu Li,Bo Han,Xiang Zhang
摘要
The efficient construction of cyclopropyl spiroindoline skeletons and the exploration of related follow-up synthetic transformations have elicited considerable interest amongst members of the chemistry community. Here, we describe a formal (2 + 1) annulation and three-component (1 + 1 + 1) cascade cyclisation via sulphur ylide cyclopropanation under mild conditions. The spiro-cyclopropyl iminoindoline moiety can be readily transformed into another medicinally interesting pyrrolo[3,4-c]quinoline framework through a novel rearrangement process.
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