核酸
寡核苷酸
组合化学
寡核苷酸合成
化学
纳米技术
生物化学
DNA
材料科学
作者
Arkaja Goswami,Ashok K. Prasad,Jyotirmoy Maity,Neerja Khaneja
标识
DOI:10.1080/15257770.2022.2052316
摘要
A large number of Locked Nucleic Acids (LNAs) with variety of modifications and restricted conformations have been developed in the last few decades. These modifications have significantly improved the biological properties of oligonucleotides, when LNAs moieties were incorporated into them. Herein, the synthesis and applications of these modified locked nucleic acids as antisense oligonucleotides are discussed.Supplemental data for this article is available online at https://doi.org/10.1080/15257770.2022.2052316 .
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