医学
维拉帕米
钙通道
心力衰竭
心绞痛
心脏病学
临床试验
毒品类别
钙通道阻滞剂
血压
内科学
钙
曲多普利
药理学
药品
心肌梗塞
血管紧张素转换酶抑制剂
血管紧张素转换酶
作者
Mark J. Eisenberg,Anya C. Brox,Alain Bestawros
标识
DOI:10.1016/j.amjmed.2003.08.027
摘要
This paper reviews the current literature pertaining to calcium channel blockers, including their classification, properties, and therapeutic indications, in light of several recent trials that have addressed their safety. Calcium channel blockers are a structurally and functionally heterogeneous group of medications that are used widely to control blood pressure and manage symptoms of angina. They are classified as dihydropyridines or nondihydropyridines. As a class, they are well tolerated and are associated with few side effects. The question of whether they may precipitate cardiovascular events has been largely settled by recent trials, such as the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), the International Verapamil Slow-Release/Trandolapril Study (INVEST), and the Controlled Onset Verapamil Investigation of Cardiovascular Endpoints (CONVINCE) study, in which no such association was found. Even so, the use of these agents has been linked with an increased risk of heart failure. Thus, long-acting calcium channel blockers may be safely used in the management of hypertension and angina. However, as a class, they are not as protective as other antihypertensive agents against heart failure.
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