Enantioselective Synthesis of β‐Lactam Carried C(3) Functionality via Ester Enolate‐Imine Condensation

Abstract Enantioselective synthesis of optically active β‐lactam via ester enolate‐imine condensation using homochiral ester 16 and imine 17 provided β‐lactam 18a in 77% cc. Lactam 18a, carried C(3) functionality on β‐lactam nuclei, provided a potential precursor toward a synthesis of dipeptide antibiotic.