生物
基因复制
基因组
遗传学
转录因子
基因
节段重复
基因家族
系统发育学
系统发育树
进化生物学
计算生物学
作者
Zoe Hilioti,Ioannis Ganopoulos,Ioannis Bossis,Athanasios Tsaftaris
出处
期刊:Gene
[Elsevier]
日期:2014-06-01
卷期号:543 (2): 220-233
被引量:12
标识
DOI:10.1016/j.gene.2014.04.019
摘要
Transcription factor function is crucial for eukaryotic systems. The presence of transcription factor families in genomes represents a significant technical challenge for functional studies. To understand their function, we must understand how they evolved and maintained by organisms. Based on genome scale searches for homologs of LEAFY COTYLEDON-LIKE (L1L; AtNF-YB6), NF-YB transcription factor, we report the discovery and annotation of a complete repertoire of thirteen novel genes that belong to the L1L paralogous gene family of Solanum lycopersicum. Gene duplication events within the species resulted in the expansion of the L1L family. Sequence and structure-based phylogenetic analyses revealed two distinct groups of L1Ls in tomato. Natural selection appears to have contributed to the asymmetric evolution of paralogs. Our results point to key differences among SlL1L paralogs in the presence of motifs, structural features, cysteine composition and expression patterns during plant and fruit development. Furthermore, differences in the binding domains of L1L members suggest that some of them evolved new binding specificities. These results reveal dramatic functional diversification of L1L paralogs for their maintenance in tomato genome. Our comprehensive insights on tomato L1L family should provide the basis for further functional and genetic experimentation.
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